Real-World Evaluation of Treatment Patterns and Resource Utilization in Japanese Patients with Multiple Myeloma Using the MDV Database

Client Challenge:

Putnam PHMR’s client needed a detailed description of multiple myeloma treatment patterns and
resource utilization in Japanese patients.

Our Approach:

Using the data source of The Medical Data Vision (MDV) database (2008 – 2015), our RWE and
Biostatistics team worked to:

• Describe the MM drug strategies dispensed in 1st line, 2nd line, and 3rd line.
• Estimate the probabilities and the time to treatment-related events (switch, add-on, reduction
  and discontinuation).
• Estimate the healthcare resource uses for the observed treatment pathways.
• Estimate the probabilities and the time to of MM-related complication events (e.g.
  hypercalcemia, renal insufficiency, anaemia, skeletal lesions)​.
• Estimate the probabilities and the time to treatment-related adverse events.​

The Results

With our RWE and Biostatistics team’s findings, we came to the solution of generating a retrospective longitudinal observational cohort study exploring the treatment pattern of patients and related- outcomes in patients with multiple myeloma​.